Explain how sickle cell anemia come to arise

Question: Explain how sickle cell anemia come to arise
- Keywords:
  sickle cell
Asked by Tobias lugwe on 16 Jul 2025. This question was also asked by bury22rue.
- Justa Mwangi answered on 16 Jul 2025:
  
  Sickle cell anemia arises from inheriting two copies of a mutated hemoglobin gene (one from each parent), leading to the production of abnormal hemoglobin (HbS) and sickle-shaped red blood cells. These abnormal cells can block blood flow, causing various health problems. If only one copy of the mutated gene is inherited, individuals have sickle cell trait, generally not experiencing symptoms but potentially passing the gene to their children.
- Jared Maina answered on 21 Jul 2025:
  
  Sickle cell disease is an inherited condition that changes red blood cells from round discs to crescent shapes. These faulty cells can block blood flow, leading to pain, fatigue, and other health problems.
  The disease is most common among people of African descent but also occurs in parts of India, the Middle East, and Southern Europe. A child develops sickle cell only when they inherit the faulty haemoglobin gene from both parents; inheriting just one copy makes you a carrier without symptoms. When both parents are carriers, each pregnancy has a 25 percent chance of producing a child with sickle cell, a 50 percent chance of a carrier child, and a 25 percent chance of a completely unaffected child.

Question: Explain how sickle cell anemia come to arise